TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro.

نویسندگان

  • Cécile L Tremblay
  • Françoise Giguel
  • Yongbiao Guan
  • Ting-Chao Chou
  • Katsunori Takashima
  • Martin S Hirsch
چکیده

TAK-220 is a CCR5 antagonist, part of the new class of anti-human immunodeficiency virus type 1 (anti-HIV-1) entry inhibitors. We evaluated the anti-HIV-1 interactions between TAK-220 and various antiretrovirals in vitro. Synergy was observed with all drugs at the 90 and 95% inhibitory concentrations. The favorable drug interactions observed suggest that further clinical evaluation is warranted.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 49 8  شماره 

صفحات  -

تاریخ انتشار 2005